Marc W. Kirschner Ph.D.

PI

Marc W. Kirschner, Ph.D. was the founding chair of the Department of Systems Biology. He and John Gerhart are co-authors of Cells, Embryos, and Evolution (Blackwell, 1997) and their newly published book, The Plausibility of Life: Resolving Darwin¹s Dilemma (Yale University Press, 2005). Dr. Kirschner was elected Foreign Member of the Royal Society of London and as a Foreign Member of the Academia Europaea in 1999.  In December 2003, Kirschner received the E.B. Wilson Medal, the American Society of Cell Biology¹s highest scientific honor. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and has served on the Advisory Committee to the Director of the National Institutes of Health and as President of the American Society for Cell Biology. Dr. Kirschner¹s laboratory investigates three broad, diverse areas: regulation of the cell cycle, the role of cytoskeleton in cell morphogenesis, and mechanisms of establishing the basic vertebrate body plan.

In 1993, Dr. Kirschner arrived at Harvard Medical School from the University of California, San Francisco, where he had served on the faculty as Professor for fifteen years. Dr. Kirschner graduated from Northwestern University in 1966 and received his Ph.D. from the University of California, Berkeley in 1971. Following postdoctoral research at Berkeley and at the University of Oxford, he was appointed an Assistant Professor at Princeton University in 1972.

Recent publications:

Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science. 2018 Apr 26. pii: eaar5780. doi: 10.1126/science.aar5780. PubMed PMID: 29700227

Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10838-E10847. doi: 10.1073/pnas.1709207114. Epub 2017 Nov 28. PubMed PMID: 29183978; PubMed Central PMCID: PMC5740657

Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017 Jul 20;67(2):322-333.e6. doi: 10.1016/j.molcel.2017.06.007. Epub 2017 Jul 6. PubMed PMID: 28689658. PMC5580496.

Email: 
Phone: 
617-432-2250
Address: 

200 Longwood Avenue Warren Alpert 536 Boston, MA 02115