Publications
Found 364 results
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts.. Methods Enzymol. 406:156-73.
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2006. Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida.. Nature. 444(7115):85-8.
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2006. Dorsoventral patterning in hemichordates: insights into early chordate evolution.. PLoS Biol. 4(9):e291.
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2006. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.. PLoS Biol. 4(2):e38.
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2006. In vitro reconstitution of cdc42-mediated actin assembly using purified components.. Methods Enzymol. 406:174-90.
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2006. Obituary: Reinhart Heinrich (1946-2006).. Nature. 444(7120):700.
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2006. Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements.. Mol Cell Proteomics. 5(1):172-81.
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2006. .
2006. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins.. J Am Soc Mass Spectrom. 16(12):1985-99.
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2005. Domain structure of separase and its binding to securin as determined by EM.. Nat Struct Mol Biol. 12(6):552-3.
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2005. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator.. Dev Cell. 8(3):435-42.
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2005. Hemichordates and the origin of chordates.. Curr Opin Genet Dev. 15(4):461-7.
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2005. Identification of ubiquitin ligase substrates by in vitro expression cloning.. Methods Enzymol. 399:404-14.
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2005. The meaning of systems biology.. Cell. 121(4):503-4.
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2005. A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.. Development. 132(20):4599-610.
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2005. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.. Mol Cell. 18(2):185-200.
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2005. Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS.. Proc Natl Acad Sci U S A. 102(11):3948-53.
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2005. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.. Nature. 432(7017):588-95.
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2004. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.. Nat Struct Mol Biol. 11(8):747-55.
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2004. Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.. J Cell Biol. 164(3):407-16.
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2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.. Nature. 428(6979):194-8.
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2004. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.. Mol Cell Biol. 24(12):5269-80.
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2004. Hemichordate embryos: procurement, culture, and basic methods.. Methods Cell Biol. 74:171-94.
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2004. Purification and architecture of the ubiquitous Wave complex.. Proc Natl Acad Sci U S A. 101(13):4379-83.
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2004. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.. Proc Natl Acad Sci U S A. 101(32):11821-6.
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2004. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.. Cell. 118(2):203-16.
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2004. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex.. Nat Cell Biol. 6(2):129-37.
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2004. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS.. Proc Natl Acad Sci U S A. 100(12):6940-5.
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2003. Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.. Cell. 113(7):853-65.
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2003. Graded positional information: interpretation for both fate and guidance.. Cell. 113(4):425-8.
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2003. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis.. Proc Natl Acad Sci U S A. 100(7):3925-9.
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2003. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.. PLoS Biol. 1(1):E10.
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2003. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm.. Development. 130(4):805-16.
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2003. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.. Cell. 113(1):101-13.
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2003. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.. EMBO J. 22(14):3602-12.
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2003. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula.. Development. 130(9):1961-72.
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2003. Anaphase specific auto-cleavage of separase.. FEBS Lett. 528(1-3):246-50.
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2002. Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway.. Cancer Res. 62(13):3842-9.
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2002. Intracellular signal propagation in a two-dimensional autocatalytic reaction model.. Phys Rev E Stat Nonlin Soft Matter Phys. 66(3 Pt 1):031905.
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2002. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.. Nature. 418(6899):790-3.
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2002. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.. J Biol Chem. 277(38):34727-35.
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2002. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.. Nat Cell Biol. 4(7):509-13.
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2002. Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development.. Dev Cell. 3(4):557-68.
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2002. Timing of events in mitosis.. Curr Biol. 12(2):105-14.
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2002. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.. Mol Cell. 8(5):1027-39.
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2001. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.. Proc Natl Acad Sci U S A. 98(19):10624-9.
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2001. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family.. Proc Natl Acad Sci U S A. 98(20):11306-11.
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2001. Dual inhibition of sister chromatid separation at metaphase.. Cell. 107(6):715-26.
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2001. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities.. Proc Natl Acad Sci U S A. 98(23):13066-71.
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2001. Information access. Building a "GenBank" of the published literature.. Science. 291(5512):2318-9.
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2001. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.. Genes Dev. 15(14):1759-64.
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2001. Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation.. Dev Cell. 1(4):553-65.
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2001. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.. J Biol Chem. 276(28):26448-52.
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2001. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon.. J Cell Biol. 154(5):983-93.
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2001. Pin1 acts catalytically to promote a conformational change in Cdc25.. Mol Cell. 7(5):1071-83.
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2001. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.. Genes Dev. 15(18):2396-407.
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2001. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.. Curr Biol. 10(13):758-65.
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2000. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts.. Mol Cell. 5(3):523-32.
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2000. The fate of cells in the tailbud of Xenopus laevis.. Development. 127(2):255-67.
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2000. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.. Genes Dev. 14(6):655-65.
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2000. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.. Neuron. 28(3):665-79.
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2000. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.. J Cell Biol. 150(6):1299-310.
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2000. Molecular "vitalism".. Cell. 100(1):79-88.
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2000. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.. Nat Struct Biol. 7(3):224-9.
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2000. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP.. Proc Natl Acad Sci U S A. 97(23):12631-6.
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2000. Control of mitotic transitions by the anaphase-promoting complex.. Philos Trans R Soc Lond B Biol Sci. 354(1389):1583-90.
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1999. Easy passage: germline transgenesis in frogs.. Proc Natl Acad Sci U S A. 96(25):14189-90.
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1999. E-publication proposal.. Science. 285(5430):1013.
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1999. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors.. Curr Biol. 9(4):174-85.
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1999. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.. Science. 285(5426):418-22.
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1999. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.. Cell. 97(2):221-31.
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1999. Intracellular proteolysis.. Trends Cell Biol. 9(12):M42-5.
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1999. Microtubule bending and breaking in living fibroblast cells.. J Cell Sci. 112 ( Pt 19):3283-8.
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1999. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2.. Dev Biol. 207(1):119-32.
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1999. Quantitative measurement of the catastrophe rate of dynamic microtubules.. Cell Motil Cytoskeleton. 43(1):43-51.
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1999. A visit to the Hubrecht laboratory.. Int J Dev Biol. 43(7):629-31.
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1999. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42.. Proc Natl Acad Sci U S A. 95(26):15362-7.
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1998. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells.. Proc Natl Acad Sci U S A. 95(12):6785-90.
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1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.. Genes Dev. 12(12):1871-83.
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1998. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins.. Proc Natl Acad Sci U S A. 95(19):11251-6.
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1998. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts.. J Cell Biol. 140(5):1125-36.
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1998. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.. Mol Cell. 2(2):163-71.
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1998. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.. Genes Dev. 12(5):706-20.
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1998. Evolvability.. Proc Natl Acad Sci U S A. 95(15):8420-7.
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1998. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation.. Development. 125(16):3247-58.
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1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis.. Cell. 93(6):1043-53.
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1998. Identification of a cullin homology region in a subunit of the anaphase-promoting complex.. Science. 279(5354):1219-22.
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1998. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.. Genes Dev. 12(18):2842-51.
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1998. BIME joins the destruction team.. Trends Cell Biol. 7(2):49.
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1997. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.. Science. 278(5336):294-8.
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1997. Expression cloning in the test tube.. Science. 277(5328):973-4.
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1997. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.. Science. 277(5332):1672-6.
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1997. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.. Genes Dev. 11(11):1409-21.
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1997. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.. Science. 278(5345):1957-60.
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1997. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos.. Development. 124(23):4739-48.
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1997. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development.. Methods Enzymol. 283:83-99.
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1997. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.. J Biol Chem. 272(47):29449-53.
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1997. The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm.. Curr Biol. 7(6):451-4.
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1997. Systematic identification of mitotic phosphoproteins.. Curr Biol. 7(5):338-48.
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