Department of Systems Biology
Harvard Medical School
Harvard University

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Research

We are broadly interested in fundamental questions in cell and developmental biology, especially around biological organization in space and time, that we feel still do not have satisfactory answers. The big themes we work on are:

Single Cell Transcriptomics, Proteomics and Developmental Strategies

Pathways of Ubiquitin Mediated Degradation

Importance of Weak Protein-Protein Interactions

Cell Size

Recent Publications

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length
Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution

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