Department of Systems Biology
Harvard Medical School
Harvard University

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Research

We are broadly interested in fundamental questions in cell and developmental biology, especially around biological organization in space and time, that we feel still do not have satisfactory answers. The big themes we work on are:

Single Cell Transcriptomics, Proteomics and Developmental Strategies

Pathways of Ubiquitin Mediated Degradation

Importance of Weak Protein-Protein Interactions

Cell Size

Recent Publications

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.
Hippo pathway mediates resistance to cytotoxic drugs.
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

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