Department of Systems Biology
Harvard Medical School
Harvard University

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Research

We are broadly interested in fundamental questions in cell and developmental biology, especially around biological organization in space and time, that we feel still do not have satisfactory answers. The big themes we work on are:

Single Cell Transcriptomics, Proteomics and Developmental Strategies

Pathways of Ubiquitin Mediated Degradation

Importance of Weak Protein-Protein Interactions

Cell Size

Recent Publications

Bayesian Confidence Intervals for Multiplexed Proteomics Integrate Ion-statistics with Peptide Quantification Concordance.
Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration.
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.

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