Publications

Found 350 results
2015
Ginzberg MB, Kafri R, Kirschner MW.  2015.  Cell biology. On being the right (cell) size.. Science. 348(6236):1245075.
Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW.  2015.  Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.. Cell. 161(5):1187-201.
Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F et al..  2015.  Hemichordate genomes and deuterostome origins.. Nature. 527(7579):459-65.
Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ et al..  2015.  The Nuclear Proteome of a Vertebrate.. Curr Biol. 25(20):2663-71.
Alberts B, Kirschner MW, Tilghman S, Varmus H.  2015.  Opinion: Addressing systemic problems in the biomedical research enterprise.. Proc Natl Acad Sci U S A. 112(7):1912-3.
Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW.  2015.  On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.. Dev Cell. 35(3):383-94.
Son S, Kang JHo, Oh S, Kirschner MW, Mitchison TJ, Manalis S.  2015.  Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.. J Cell Biol. 211(4):757-63.
Lu Y, Wang W, Kirschner MW.  2015.  Specificity of the anaphase-promoting complex: a single-molecule study.. Science. 348(6231):1248737.
Lu Y, Lee B-hoon, King RW, Finley D, Kirschner MW.  2015.  Substrate degradation by the proteasome: a single-molecule kinetic analysis.. Science. 348(6231):1250834.
2014
Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J et al..  2014.  APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.. Dev Cell. 29(4):377-91.
Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BMo et al..  2014.  Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.. Nature. 508(7497):541-5.
Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi SP, Kirschner MW.  2014.  Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database.. Curr Biol. 24(13):1467-75.
Gujral TSingh, Peshkin L, Kirschner MW.  2014.  Exploiting polypharmacology for drug target deconvolution.. Proc Natl Acad Sci U S A. 111(13):5048-53.
Wang W, Wu T, Kirschner MW.  2014.  The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.. Elife. 3:e03083.
Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S.  2014.  Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated.. J Am Chem Soc. 136(13):4845-8.
Li VC, Kirschner MW.  2014.  Molecular ties between the cell cycle and differentiation in embryonic stem cells.. Proc Natl Acad Sci U S A. 111(26):9503-8.
Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G.  2014.  A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.. Cell. 159(4):844-56.
Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ.  2014.  A nontranscriptional role for Oct4 in the regulation of mitotic entry.. Proc Natl Acad Sci U S A. 111(44):15768-73.
Satoh N, Tagawa K, Lowe CJ, Yu J-K, Kawashima T, Takahashi H, Ogasawara M, Kirschner MW, Hisata K, Su Y-H et al..  2014.  On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates.. Genesis. 52(12):925-34.
Merbl Y, Kirschner MW.  2014.  Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems.. Curr Protoc Protein Sci. 77:27.8.1-27.8.13.
Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ.  2014.  Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.. J Biol Chem. 289(42):28942-55.
Alberts B, Kirschner MW, Tilghman S, Varmus H.  2014.  Rescuing US biomedical research from its systemic flaws.. Proc Natl Acad Sci U S A. 111(16):5773-7.
2013
Kirschner MW.  2013.  Beyond Darwin: evolvability and the generation of novelty.. BMC Biol. 11:110.
Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW et al..  2013.  Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.. J Biol Chem. 288(5):2976-85.
Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.  2013.  Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.. Nature. 494(7438):480-3.
Wang W, Kirschner MW.  2013.  Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.. Nat Cell Biol. 15(7):797-806.
Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW.  2013.  Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.. Proc Natl Acad Sci U S A. 110(30):E2848-53.
Cooper KL, Oh S, Sung Y, Dasari RR, Kirschner MW, Tabin CJ.  2013.  Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions.. Nature. 495(7441):375-8.
Kirschner MW.  2013.  A perverted view of "impact".. Science. 340(6138):1265.
Gallop JL, Walrant A, Cantley LC, Kirschner MW.  2013.  Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.. Proc Natl Acad Sci U S A. 110(18):7193-8.
Merbl Y, Refour P, Patel H, Springer M, Kirschner MW.  2013.  Profiling of ubiquitin-like modifications reveals features of mitotic control.. Cell. 152(5):1160-72.
Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW et al..  2013.  SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.. Cell Rep. 4(4):803-16.
Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW.  2013.  Size homeostasis in adherent cells studied by synthetic phase microscopy.. Proc Natl Acad Sci U S A. 110(41):16687-92.
2011
Ballabeni A, Park I-H, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW.  2011.  Cell cycle adaptations of embryonic stem cells.. Proc Natl Acad Sci U S A. 108(48):19252-7.
Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner MW, Guillemot F, Philpott A.  2011.  Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.. Development. 138(19):4267-77.
Kirschner MW, Shapiro L, McAdams H, Almouzni G, Sharp PA, Young RA, Alon U.  2011.  Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? Mol Cell. 42(4):403-4.
Yanai I, Peshkin L, Jorgensen P, Kirschner MW.  2011.  Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility.. Dev Cell. 20(4):483-96.
Kirschner MW.  2011.  Marc Kirschner. Interview by Asher Mullard.. Nat Rev Drug Discov. 10(12):894.
Tzur A, Moore JK, Jorgensen P, Shapiro HM, Kirschner MW.  2011.  Optimizing optical flow cytometry for cell volume-based sorting and analysis.. PLoS One. 6(1):e16053.
Merbl Y, Kirschner MW.  2011.  Protein microarrays for genome-wide posttranslational modification analysis.. Wiley Interdiscip Rev Syst Biol Med. 3(3):347-56.
Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW.  2011.  Remodeling of the metabolome during early frog development.. PLoS One. 6(2):e16881.
Darras S, Gerhart J, Terasaki M, Kirschner MW, Lowe CJ.  2011.  β-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii.. Development. 138(5):959-70.
2010
Kirschner MW.  2010.  Cell biology as a world view.. Mol Biol Cell. 21(22):3803.
Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC.  2010.  Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.. Genes Dev. 24(22):2531-42.
Springer M, Weissman JS, Kirschner MW.  2010.  A general lack of compensation for gene dosage in yeast.. Mol Syst Biol. 6:368.
DeLuna A, Springer M, Kirschner MW, Kishony R.  2010.  Need-based up-regulation of protein levels in response to deletion of their duplicate genes.. PLoS Biol. 8(3):e1000347.
Song EJoo, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, J Harper W, Elledge SJ, Kirschner MW, Rape M.  2010.  The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.. Genes Dev. 24(13):1434-47.
Deibler RW, Kirschner MW.  2010.  Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts.. Mol Cell. 37(6):753-67.
Lee K, Gallop JL, Rambani K, Kirschner MW.  2010.  Self-assembly of filopodia-like structures on supported lipid bilayers.. Science. 329(5997):1341-5.
Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW.  2010.  UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.. Proc Natl Acad Sci U S A. 107(4):1355-60.
Godin M, Delgado FFeijó, Son S, Grover WH, Bryan AK, Tzur A, Jorgensen P, Payer K, Grossman AD, Kirschner MW et al..  2010.  Using buoyant mass to measure the growth of single cells.. Nat Methods. 7(5):387-90.
2009
Lebensohn AM, Kirschner MW.  2009.  Activation of the WAVE complex by coincident signals controls actin assembly.. Mol Cell. 36(3):512-24.
Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner MW, Dyson N, Wei W.  2009.  Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.. Mol Biol Cell. 20(14):3305-16.
Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW.  2009.  Cell growth and size homeostasis in proliferating animal cells.. Science. 325(5937):167-71.
Goentoro L, Kirschner MW.  2009.  Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.. Mol Cell. 36(5):872-84.
Singh S, Springer M, Steen J, Kirschner MW, Steen H.  2009.  FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides.. J Proteome Res. 8(5):2201-10.
Goentoro L, Shoval O, Kirschner MW, Alon U.  2009.  The incoherent feedforward loop can provide fold-change detection in gene regulation.. Mol Cell. 36(5):894-9.
Merbl Y, Kirschner MW.  2009.  Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.. Proc Natl Acad Sci U S A. 106(8):2543-8.
Jorgensen P, Steen JAJ, Steen H, Kirschner MW.  2009.  The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus.. Development. 136(9):1539-48.
Huang S-MA, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S et al..  2009.  Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.. Nature. 461(7264):614-20.
2006
Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW.  2006.  Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.. Chem Biol. 13(4):443-52.
Lebensohn AM, Ma L, Ho H-YHenry, Kirschner MW.  2006.  Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts.. Methods Enzymol. 406:156-73.
Bourlat SJ, Juliusdottir T, Lowe CJ, Freeman R, Aronowicz J, Kirschner MW, Lander ES, Thorndyke M, Nakano H, Kohn AB et al..  2006.  Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida.. Nature. 444(7115):85-8.
Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C et al..  2006.  Dorsoventral patterning in hemichordates: insights into early chordate evolution.. PLoS Biol. 4(9):e291.
Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.  2006.  Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.. PLoS Biol. 4(2):e38.
Ho H-YHenry, Rohatgi R, Lebensohn AM, Kirschner MW.  2006.  In vitro reconstitution of cdc42-mediated actin assembly using purified components.. Methods Enzymol. 406:174-90.
Kirschner MW.  2006.  Obituary: Reinhart Heinrich (1946-2006).. Nature. 444(7120):700.
Steen H, Jebanathirajah JA, Rush J, Morrice N, Kirschner MW.  2006.  Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements.. Mol Cell Proteomics. 5(1):172-81.
Rape M, Reddy SK, Kirschner MW.  2006.  The processivity of multiubiquitination by the APC determines the order of substrate degradation.. Cell. 124(1):89-103.

Pages