Publications
Found 364 results
Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.. Dev Biol. 464(1):71-87.
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2020. Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth.. Proc Natl Acad Sci U S A. 117(44):27388-27399.
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2020. Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.. Mol Cell. 77(6):1294-1306.e5.
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2020. Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.. Proc Natl Acad Sci U S A. 117(28):16690-16701.
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2020. Bayesian Confidence Intervals for Multiplexed Proteomics Integrate Ion-statistics with Peptide Quantification Concordance.. Mol Cell Proteomics. 18(10):2108-2120.
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2019. Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration.. Cell Rep. 29(4):1027-1040.e6.
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2019. The genome of the giant Nomura's jellyfish sheds light on the early evolution of active predation.. BMC Biol. 17(1):28.
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2019. Quantitative Proteomics Reveals Remodeling of Protein Repertoire Across Life Phases of Daphnia pulex.. Proteomics. 19(24):e1900155.
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2018.
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science. 360(6392)
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2018. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.. Science. 361(6399):290-295.
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2018. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.. Cancer Discov. 7(4):424-441.
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2017. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.. Mol Cell. 67(2):322-333.e6.
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2017. Hippo pathway mediates resistance to cytotoxic drugs.. Proc Natl Acad Sci U S A. 114(18):E3729-E3738.
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2017. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation.. Cell Rep. 20(3):721-736.
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2017. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg. Proc Natl Acad Sci USA. 114(50)
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2017. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.. Cell. 165(6):1440-53.
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2016. The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.. Nat Commun. 7:11370.
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2016. SCIENTIFIC COMMUNITY. Preprints for the life sciences.. Science. 352(6288):899-901.
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2016. Structural basis for dynamic regulation of the human 26S proteasome.. Proc Natl Acad Sci U S A. 113(46):12991-12996.
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2016. Cell biology. On being the right (cell) size.. Science. 348(6236):1245075.
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2015. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.. Cell. 161(5):1187-201.
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2015. Hemichordate genomes and deuterostome origins.. Nature. 527(7579):459-65.
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2015. The Nuclear Proteome of a Vertebrate.. Curr Biol. 25(20):2663-71.
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2015. Opinion: Addressing systemic problems in the biomedical research enterprise.. Proc Natl Acad Sci U S A. 112(7):1912-3.
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2015. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.. Dev Cell. 35(3):383-94.
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2015. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.. J Cell Biol. 211(4):757-63.
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2015. Specificity of the anaphase-promoting complex: a single-molecule study.. Science. 348(6231):1248737.
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2015. Substrate degradation by the proteasome: a single-molecule kinetic analysis.. Science. 348(6231):1250834.
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2015. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.. Dev Cell. 29(4):377-91.
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2014. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.. Nature. 508(7497):541-5.
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2014. Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database.. Curr Biol. 24(13):1467-75.
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2014. Exploiting polypharmacology for drug target deconvolution.. Proc Natl Acad Sci U S A. 111(13):5048-53.
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2014. The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.. Elife. 3:e03083.
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2014. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated.. J Am Chem Soc. 136(13):4845-8.
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2014. Molecular ties between the cell cycle and differentiation in embryonic stem cells.. Proc Natl Acad Sci U S A. 111(26):9503-8.
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2014. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.. Cell. 159(4):844-56.
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2014. A nontranscriptional role for Oct4 in the regulation of mitotic entry.. Proc Natl Acad Sci U S A. 111(44):15768-73.
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2014. On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates.. Genesis. 52(12):925-34.
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2014. Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems.. Curr Protoc Protein Sci. 77:27.8.1-27.8.13.
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2014. Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.. J Biol Chem. 289(42):28942-55.
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2014. Rescuing US biomedical research from its systemic flaws.. Proc Natl Acad Sci U S A. 111(16):5773-7.
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2014. Beyond Darwin: evolvability and the generation of novelty.. BMC Biol. 11:110.
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2013. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.. J Biol Chem. 288(5):2976-85.
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2013. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.. Nature. 494(7438):480-3.
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2013. Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.. Nat Cell Biol. 15(7):797-806.
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2013. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.. Proc Natl Acad Sci U S A. 110(30):E2848-53.
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2013. Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions.. Nature. 495(7441):375-8.
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2013. A perverted view of "impact".. Science. 340(6138):1265.
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2013. Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.. Proc Natl Acad Sci U S A. 110(18):7193-8.
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2013. Profiling of ubiquitin-like modifications reveals features of mitotic control.. Cell. 152(5):1160-72.
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2013. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.. Cell Rep. 4(4):803-16.
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2013. Size homeostasis in adherent cells studied by synthetic phase microscopy.. Proc Natl Acad Sci U S A. 110(41):16687-92.
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2013. Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.. Anal Chem. 84(21):9214-21.
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2012. Direct observation of mammalian cell growth and size regulation.. Nat Methods. 9(9):910-2.
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2012. Gap 1 phase length and mouse embryonic stem cell self-renewal.. Proc Natl Acad Sci U S A. 109(31):12550-5.
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2012. Identical genomic organization of two hemichordate hox clusters.. Curr Biol. 22(21):2053-8.
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2012. Kinetic responses of β-catenin specify the sites of Wnt control.. Science. 338(6112):1337-40.
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2012. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.. Science. 336(6084):1040-4.
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2012. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.. Nature. 485(7397):195-200.
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2012. Cell cycle adaptations of embryonic stem cells.. Proc Natl Acad Sci U S A. 108(48):19252-7.
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2011. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.. Development. 138(19):4267-77.
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2011. Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? Mol Cell. 42(4):403-4.
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2011. Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility.. Dev Cell. 20(4):483-96.
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2011. Marc Kirschner. Interview by Asher Mullard.. Nat Rev Drug Discov. 10(12):894.
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2011. Optimizing optical flow cytometry for cell volume-based sorting and analysis.. PLoS One. 6(1):e16053.
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2011. Protein microarrays for genome-wide posttranslational modification analysis.. Wiley Interdiscip Rev Syst Biol Med. 3(3):347-56.
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2011. Remodeling of the metabolome during early frog development.. PLoS One. 6(2):e16881.
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2011. Cell biology as a world view.. Mol Biol Cell. 21(22):3803.
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2010. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.. Genes Dev. 24(22):2531-42.
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2010. A general lack of compensation for gene dosage in yeast.. Mol Syst Biol. 6:368.
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2010. Need-based up-regulation of protein levels in response to deletion of their duplicate genes.. PLoS Biol. 8(3):e1000347.
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2010. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.. Genes Dev. 24(13):1434-47.
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2010. Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts.. Mol Cell. 37(6):753-67.
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2010. Self-assembly of filopodia-like structures on supported lipid bilayers.. Science. 329(5997):1341-5.
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2010. UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.. Proc Natl Acad Sci U S A. 107(4):1355-60.
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2010. Using buoyant mass to measure the growth of single cells.. Nat Methods. 7(5):387-90.
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2010. Activation of the WAVE complex by coincident signals controls actin assembly.. Mol Cell. 36(3):512-24.
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2009. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.. Mol Biol Cell. 20(14):3305-16.
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2009. Cell growth and size homeostasis in proliferating animal cells.. Science. 325(5937):167-71.
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2009. Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.. Mol Cell. 36(5):872-84.
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2009. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides.. J Proteome Res. 8(5):2201-10.
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2009. The incoherent feedforward loop can provide fold-change detection in gene regulation.. Mol Cell. 36(5):894-9.
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2009. Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.. Proc Natl Acad Sci U S A. 106(8):2543-8.
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2009. The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus.. Development. 136(9):1539-48.
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2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.. Nature. 461(7264):614-20.
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2009. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.. Biol Bull. 214(3):284-302.
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2008. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis.. Proc Natl Acad Sci U S A. 105(16):6069-74.
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2008. Profile: Bruce Alberts, Science's new editor.. Science. 319(5867):1199.
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2008. An actin-based wave generator organizes cell motility.. PLoS Biol. 5(9):e221.
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2007. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.. Nature. 446(7138):876-81.
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2007. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.. J Cell Sci. 120(Pt 20):3565-77.
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2007. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition.. Cell. 128(6):1119-32.
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2007. The relationship between evolutionary and physiological variation in hemoglobin.. Proc Natl Acad Sci U S A. 104(43):16998-7003.
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2007. The theory of facilitated variation.. Proc Natl Acad Sci U S A. 104 Suppl 1:8582-9.
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2007. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.. Nature. 446(7138):921-5.
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